Nostodione A, a Novel Mitotic Spindle Poison* from a Blue-Green Alga Nostoc commune
نویسندگان
چکیده
Akio Kobayashi, Shin-ichiro Kajiyama, Kunifumi Inawaka, Hiroshi Kanzaki and Kazuyoshi Kawazu Department of Agricultural Science, Faculty of Agriculture, Okayama University, Okayama 700. Japan Z. Naturforsch. 49c, 464-470 (1994); received February 4, 1994 Nostodione A, Mitotic Spindle Poison. Blue-Green Alga, Nostoc commune, Sea-Urchin Eggs A novel antimitotic compound named Nostodione A (Nd A) was isolated from a terrestrial blue-green alga Nostoc commune. Nostodione A disturbed the mitotic spindle formation of sea-urchin eggs and gave small spindles with low birefringence density. Nostodione A. how ever. had no phytotoxicity on the germination of a dicotyledonous plant Mediccigo sativa. Based on the spectral analysis and chemical degradation, the structure of Nostodione A was elucidated.
منابع مشابه
Total synthesis of nostodione A, a cyanobacterial metabolite.
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